Regional mapping of the parathyroid hormone gene (PTH) by cytogenetic and molecular studies

Cytogenet Cell Genet. 1991;56(2):103-4. doi: 10.1159/000133059.

Abstract

The locus for the human parathyroid hormone gene (PTH) was assigned to a region proximal to 11p15.4 using restriction fragment length polymorphisms and gene dose studies performed on a patient with the Beckwith-Wiedemann syndrome accompanied with a chromosome abnormality [46,XX,-14,+der(14),t(14;11)(q32.3;p15.3)pat]. Our data suggest that PTH is localized in 11p15.3----p15.1, most likely near the border of the bands 11p15.4 and 11p15.3.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Beckwith-Wiedemann Syndrome / genetics
  • Blotting, Southern
  • Chromosome Aberrations
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • Female
  • Humans
  • Infant
  • Karyotyping
  • Male
  • Parathyroid Hormone / genetics*
  • Polymorphism, Restriction Fragment Length

Substances

  • Parathyroid Hormone