Efficacy of voriconazole in a guinea pig model of invasive trichosporonosis

Antimicrob Agents Chemother. 2006 Jun;50(6):2240-3. doi: 10.1128/AAC.00045-06.

Abstract

We have evaluated the efficacy of voriconazole (VRC) in a systemic infection by Trichosporon asahii in immunosuppressed guinea pigs. VRC was more effective than amphotericin B in prolonging survival and reducing tissue burden. The best results were obtained with VRC at 10 mg/kg of body weight/day.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / therapeutic use
  • Animals
  • Antifungal Agents / therapeutic use*
  • Colony Count, Microbial / statistics & numerical data
  • Disease Models, Animal
  • Guinea Pigs
  • Humans
  • Kidney / microbiology
  • Liver / microbiology
  • Microbial Sensitivity Tests
  • Mycoses / drug therapy*
  • Mycoses / mortality
  • Pyrimidines / therapeutic use*
  • Spleen / microbiology
  • Survival Analysis
  • Triazoles / therapeutic use*
  • Trichosporon / drug effects*
  • Trichosporon / genetics
  • Trichosporon / isolation & purification
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole