No confirmation of visual evoked potential diagnostic test for migraine

Lancet. 1991 Mar 2;337(8740):517-8. doi: 10.1016/0140-6736(91)91298-9.

Abstract

We have attempted to replicate the results of studies on a diagnostic test reported to have 90% sensitivity and 89-96% specificity for migraine. The technique is based on peak-to-peak measurements of fast background electroencephalographic activity during a visual evoked potential (VEP) study. VEP latencies and amplitudes did not differ significantly, and showed substantial overlap, between a group of eight migraine patients and ten age-matched healthy controls. We could not recognise previously described fast activity or measure it objectively by peak-to-peak measurements. We cannot confirm that measurement of fast wave activity in the VEP background is useful in diagnosis of migraine.

MeSH terms

  • Adult
  • Electroencephalography
  • Evaluation Studies as Topic
  • Evoked Potentials, Visual / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Migraine Disorders / diagnosis*
  • Migraine Disorders / physiopathology
  • Reproducibility of Results
  • Time Factors