Upstream toward the "DRiP"-ing source of the MHC class I pathway

Christopher C Norbury; Eric F Tewalt

doi:10.1016/j.immuni.2006.05.007

Upstream toward the "DRiP"-ing source of the MHC class I pathway

Immunity. 2006 May;24(5):503-6. doi: 10.1016/j.immuni.2006.05.007.

Authors

Christopher C Norbury¹, Eric F Tewalt

Affiliation

¹ Department of Microbiology and Immunology, Pennsylvania State University, Milton S. Hershey College of Medicine, Hershey, Pennsylvania 17033, USA.

PMID: 16713966
DOI: 10.1016/j.immuni.2006.05.007

Abstract

MHC class I binding peptides are generated via cytosolic degradation of a previously undefined substrate. In this issue of Immunity, pre-degradation polypeptide intermediates bound to a cytosolic chaperone is isolated.

Publication types

Comment
Review

MeSH terms

Animals
Antigen Presentation
Histocompatibility Antigens Class I / immunology*
Histocompatibility Antigens Class I / metabolism
Humans
Models, Immunological*
Peptides / immunology*
Peptides / metabolism
Signal Transduction / immunology*

Substances

Histocompatibility Antigens Class I
Peptides