Abstract
The porphyrin chromophore incorporated at the 5'-position of an oligonucleotide allows the simultaneous detection of the B- to Z-DNA transition via the porphyrin Soret band circular dichroism exciton couplet signal around 420 nm and the oligonucleotide CD region below 300 nm, at micromolar concentrations.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Circular Dichroism / methods
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DNA / chemistry*
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DNA, Z-Form / chemistry*
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Molecular Probes / chemistry
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Nucleic Acid Conformation
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Porphyrins / chemistry*
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Salts
Substances
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DNA, Z-Form
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Molecular Probes
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Porphyrins
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Salts
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DNA