Least biased target selection in probabilistic atlas construction

Med Image Comput Comput Assist Interv. 2005;8(Pt 2):419-26. doi: 10.1007/11566489_52.

Abstract

Probabilistic atlas has broad applications in medical image segmentation and registration. The most common problem building a probabilistic atlas is picking a target image upon which to map the rest of the training images. Here we present a method to choose a target image that is the closest to the mean geometry of the population under consideration as determined by bending energy. Our approach is based on forming a distance matrix based on bending energies of all pair-wise registrations and performing multidimensional scaling (MDS) on the distance matrix.

Publication types

  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Bias
  • Brain / anatomy & histology*
  • Computer Simulation
  • Databases, Factual*
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Information Storage and Retrieval / methods
  • Magnetic Resonance Imaging / methods*
  • Models, Biological
  • Models, Statistical
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Subtraction Technique*