Abstract
A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure-activity relationships were revealed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Cyclophosphamide / analogs & derivatives
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Cyclophosphamide / chemical synthesis*
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Cyclophosphamide / pharmacology*
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Inhibitory Concentration 50
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Mice
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Piperazines / chemical synthesis*
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Piperazines / pharmacology*
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Prodrugs
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Piperazines
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Prodrugs
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Spiro Compounds
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Cyclophosphamide