A new eudesmane derivative and a new fatty acid ester from Sambucus williamsii

Chem Pharm Bull (Tokyo). 2006 May;54(5):676-8. doi: 10.1248/cpb.54.676.

Abstract

1,4,13-Trihydroxy-eudesm-11(12)-ene, a new eudesmane derivative (3), (9E)-8,11,12-trihydroxyoctadecenoic acid methyl ester, a new fatty acid ester (2) and tianshic acid (1) were obtained from the stems of Sambucus williamsii. Their structures were elucidated by physiochemical properties and spectroscopic analysis. Both compounds 1 and 2 showed stimulating effects on alkaline phosphatase activity of the osteoblastic UMR106 cell about 1.5 fold at 30 mumol/l while they had no effects on cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaline Phosphatase / metabolism
  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Differentiation / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Fatty Acids / chemistry*
  • Magnetic Resonance Spectroscopy
  • Osteosarcoma / drug therapy
  • Osteosarcoma / pathology
  • Rats
  • Sambucus / chemistry*
  • Sesquiterpenes, Eudesmane / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared

Substances

  • 1,4,13-trihydroxy-eudesm-11(12)-ene
  • 8,11,12-trihydroxyoctadecenoic acid methyl ester
  • Antineoplastic Agents, Phytogenic
  • Fatty Acids
  • Sesquiterpenes, Eudesmane
  • eudesmane
  • Alkaline Phosphatase