Philinopsides E and F, two new sulfated triterpene glycosides from the sea cucumber Pentacta quadrangularis

Nat Prod Res. 2006 Apr;20(4):399-407. doi: 10.1080/14786410500185584.

Abstract

Two new sulfated triterpene glycosides, philinopside E (1) and F (2), have been isolated from the sea cucumber Pentacta quadrangularis. Their structures have been established by extensive spectral analysis (NMR and MS) and chemical evidence. Glycoside 1 showed significant cytotoxicity (Ed(50) 0.75-3.50 microg mL(-1)) against ten tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Glycosides / toxicity
  • Humans
  • Molecular Structure
  • Neoplasms / pathology
  • Sea Cucumbers / chemistry*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Triterpenes / toxicity

Substances

  • Glycosides
  • Philinopside E
  • Philinopside F
  • Triterpenes