I Siah substrate!

Douglas J Briant; Derek F Ceccarelli; Frank Sicheri

doi:10.1016/j.str.2006.03.003

I Siah substrate!

Structure. 2006 Apr;14(4):627-8. doi: 10.1016/j.str.2006.03.003.

Authors

Douglas J Briant, Derek F Ceccarelli, Frank Sicheri

PMID: 16615900
DOI: 10.1016/j.str.2006.03.003

Abstract

Proteins are targeted to the E3 RING ubiquitin ligase Siah through a PxAxVxP degron motif. In this issue of Structure, House et al. (2006) present the structural basis by which Siah recognizes its degron with high affinity and specificity.

Publication types

News
Comment

MeSH terms

Animals
Crystallography, X-Ray
Drosophila melanogaster
Nuclear Proteins / chemistry*
Protein Binding
Protein Structure, Tertiary
Substrate Specificity
Ubiquitin-Protein Ligases / chemistry*

Substances

Nuclear Proteins
Ubiquitin-Protein Ligases
seven in absentia proteins