Induction of signet ring cell carcinomas in X-irradiated hypocatalasemic mice (C3H/Cbs)

Jpn J Cancer Res. 1991 Nov;82(11):1175-7. doi: 10.1111/j.1349-7006.1991.tb01774.x.

Abstract

The stomach region of hypocatalasemic mice of both sexes was X-irradiated once with a dose of 20 Gy. Thirteen months after the irradiation, 3 out of 13 (20%) males and 2 out of 9 (15%) females were observed to have developed signet ring cell carcinomas in the glandular stomach. This finding was statistically significant (P less than 0.01 in males and P less than 0.05 in females) compared to a total absence of similar tumors in the non-irradiated controls. Local invasion of malignant tumors into muscle and subserosal layers was observed, but no metastatic tumors were found in distant organs.

Publication types

  • Comparative Study

MeSH terms

  • Acatalasia*
  • Adenocarcinoma / pathology*
  • Adenocarcinoma, Mucinous / pathology*
  • Animals
  • Female
  • Lymphatic Metastasis
  • Male
  • Mice
  • Mice, Inbred C3H
  • Neoplasms, Radiation-Induced / pathology*
  • Sex Characteristics
  • Stomach Neoplasms / pathology*
  • X-Rays