Biological response modifiers as adjuncts to stem cell transplantation

Expert Opin Biol Ther. 2006 May;6(5):467-83. doi: 10.1517/14712598.6.5.467.

Abstract

Cytokines produced by immune and non-immune cells serve as potent mediators with the properties of signal cells that coordinate the immune response. They are delivered by cells either to the systemic circulation or to the local environment. They are being used at present in the field of stem cell transplantation (SCT) in order to improve transplant outcome. This paper reviews the existing data on pre-, peri- and post-SCT treatment with cytokines.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Proliferation
  • Chemotherapy, Adjuvant
  • Clinical Trials as Topic
  • Cytokines / therapeutic use*
  • Dendritic Cells / cytology
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology
  • Hematopoiesis
  • Hematopoietic Stem Cell Mobilization
  • Hematopoietic Stem Cell Transplantation*
  • Hematopoietic Stem Cells / drug effects
  • Humans
  • Immunologic Factors / therapeutic use*
  • Immunotherapy, Adoptive*
  • Interferons / pharmacology
  • Interferons / therapeutic use
  • Interleukins / therapeutic use
  • Killer Cells, Natural / cytology
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / immunology
  • Neoplasms / drug therapy
  • Neoplasms / immunology
  • Neoplasms / surgery
  • Neoplasms / therapy*

Substances

  • Cytokines
  • Immunologic Factors
  • Interleukins
  • Interferons