[Synthesis and toxicity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine]

V Sunel; Anca Ciobanu; Lenuţa Profire; Cristina Băsu

[Synthesis and toxicity of some new (sulfon-amidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine]

Rev Med Chir Soc Med Nat Iasi. 2005 Jul-Sep;109(3):671-5.

[Article in Romanian]

Authors

V Sunel¹, Anca Ciobanu, Lenuţa Profire, Cristina Băsu

Affiliation

¹ Universitatea Al. I. Cuza Iaşi, Facultatea de Chimie.

PMID: 16607771

Abstract

In order to obtain new compounds with potential antibacterial activity some new (sulfonamidophenyl)-amide derivatives of N-(m-nitrobenzoil)-D,L-asparagine have been synthesized. The compounds have been obtained by decyclization reaction of 2-(m-nitrophenyl)-4-(beta-amidomethyl)-delta2-oxazolinone with various sulfonamides. A toxicity study with determination of DL50 value has also been realized.

Publication types

English Abstract

MeSH terms

Animals
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / pharmacology
Antimetabolites / chemical synthesis
Antimetabolites / pharmacology
Asparagine / analogs & derivatives
Asparagine / chemical synthesis*
Asparagine / toxicity*
Lethal Dose 50
Male
Mice
Models, Animal
Sulfonamides / chemical synthesis*
Sulfonamides / toxicity*

Substances

Anti-Bacterial Agents
Antimetabolites
Sulfonamides
Asparagine