Substrate specificity of peptide adsorption: a model study

Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Feb;73(2 Pt 1):020901. doi: 10.1103/PhysRevE.73.020901. Epub 2006 Feb 17.

Abstract

Applying the contact density chain-growth algorithm to lattice heteropolymers, we identify the conformational transitions of a nongrafted hydrophobic-polar heteropolymer with 103 residues in the vicinity of a polar, a hydrophobic, and a uniformly attractive substrate. Introducing only two system parameters, the numbers of surface contacts and intrinsic hydrophobic contacts, respectively, we obtain surprisingly complex temperature and solvent dependent, substrate-specific pseudophase diagrams.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Amino Acids / chemistry*
  • Binding Sites
  • Computer Simulation
  • Models, Chemical*
  • Peptides / chemistry*
  • Protein Binding
  • Solvents / chemistry*
  • Structure-Activity Relationship
  • Substrate Specificity

Substances

  • Amino Acids
  • Peptides
  • Solvents