Abstract
[reaction: see text] Thionation of amides, 1,4-diketones, N-(2-oxoalkyl)amides, N,N'-acylhydrazines, and acyl-protected uridines with the use of a fluorous analogue of the Lawesson's reagent leads to thioamides, thiophenes, 1,3-thiazoles, 1,3,4-thiadiazoles, and acyl-protected 4-thiouridines. The isolation of the final products in high yields is achieved in most cases by a simple filtration (fluorous solid-phase extraction).
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Combinatorial Chemistry Techniques*
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Indicators and Reagents
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Molecular Structure
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Organothiophosphorus Compounds / chemistry*
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Sulfur Compounds / chemical synthesis*
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Sulfur Compounds / chemistry*
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Thiazoles / chemical synthesis*
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Thiazoles / chemistry
Substances
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Indicators and Reagents
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Organothiophosphorus Compounds
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Sulfur Compounds
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Thiazoles
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2,4-bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane-2,4-disulfide