Abstract
Mycobacterium tuberculosis and Mycobacterium smegmatis MutT1, MutT2, MutT3, and Rv3908 (MutT4) enzymes were screened for an antimutator role. Results indicate that both MutT1, in M. tuberculosis and M. smegmatis, and MutT4, in M. smegmatis, have that role. Furthermore, an 8-oxo-guanosine triphosphatase function for MutT1 and MutT2 is suggested.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Gene Deletion
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Genes, Bacterial
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Guanosine Triphosphate / analogs & derivatives
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Guanosine Triphosphate / metabolism
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Mutagenesis, Insertional
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Mutation
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Mycobacterium smegmatis / enzymology*
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Mycobacterium smegmatis / genetics
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Mycobacterium smegmatis / physiology
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Mycobacterium tuberculosis / enzymology*
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Mycobacterium tuberculosis / genetics
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Mycobacterium tuberculosis / physiology
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Nucleotides / metabolism
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Nudix Hydrolases
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Pyrophosphatases / genetics*
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Pyrophosphatases / isolation & purification
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Pyrophosphatases / physiology*
Substances
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Nucleotides
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8-hydroxyguanosine triphosphate
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Guanosine Triphosphate
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Pyrophosphatases