Synthesis and biological action of 1-aminomethyl derivatives of 3-R-4-phenyl-delta2-1,2,4-triazoline-5-thione

Acta Pol Pharm. 2005 Nov-Dec;62(6):443-9.

Abstract

4-Phenyl-1,2,4-triazoline-5-thione [I] and 4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione [II] were subjected to the reaction of aminomethylation with piperazine derivatives. Compounds [III] and [IX] were screened for their antibacterial activities.

MeSH terms

  • Amines / chemical synthesis*
  • Amines / chemistry
  • Amines / pharmacology
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Structure-Activity Relationship
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry
  • Triazoles / pharmacology

Substances

  • Amines
  • Anti-Bacterial Agents
  • Triazoles