Cytokines in atopic diseases: revisiting the Th2 dogma

Eur J Dermatol. 2006 Mar-Apr;16(2):103-13.

Abstract

In the field of allergic diseases, extensive research has demonstrated the implication of a strong TH2 activation that both initiates and maintains in situ inflammation with the help of TH2 cytokines. However, as anti-TH2 cytokines therapy is not sufficient to suppress the disease, a more complex immunological mechanism is suspected. In this review, we will revisit the TH2 dogma in allergic diseases, propose a possible implication of TH1 inflammation correlated with the severity of atopic disease, to conclude with the therapeutic solutions envisaged.

Publication types

  • Review

MeSH terms

  • Cytokines / physiology*
  • Humans
  • Hypersensitivity, Immediate / immunology*
  • Th2 Cells / immunology*

Substances

  • Cytokines