Intracytoplasmic sperm injection may lead to vertical transmission, expansion, and de novo occurrence of Y-chromosome microdeletions in male fetuses

Sook-Hwan Lee; So-Yeon Ahn; Kyo-Won Lee; KyuBum Kwack; Hye-Sun Jun; Kwang-Yul Cha

doi:10.1016/j.fertnstert.2005.10.034

Intracytoplasmic sperm injection may lead to vertical transmission, expansion, and de novo occurrence of Y-chromosome microdeletions in male fetuses

Fertil Steril. 2006 May;85(5):1512-5. doi: 10.1016/j.fertnstert.2005.10.034. Epub 2006 Mar 29.

Authors

Sook-Hwan Lee¹, So-Yeon Ahn, Kyo-Won Lee, KyuBum Kwack, Hye-Sun Jun, Kwang-Yul Cha

Affiliation

¹ Infertility Medical Center of CHA General Hospital, CHA Research Institute, Seoul, Korea.

PMID: 16566932
DOI: 10.1016/j.fertnstert.2005.10.034

Abstract

Y-chromosome microdeletion in male fetuses conceived by intracytoplasmic sperm injection (ICSI) was screened by polymerase chain reaction for sequence-tagged sites in azoospermia factor (AZF)-b and AZFc regions. Treatment with ICSI may lead to vertical transmission, expansion, and de novo Y-chromosome microdeletion in male fetuses.

Publication types

Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Deletion*
Chromosome Disorders / genetics*
Chromosomes, Human, Y / genetics*
Humans
Incidence
Infectious Disease Transmission, Vertical*
Infertility, Male / genetics*
Infertility, Male / therapy*
Male
Mosaicism
Sex Factors
Sperm Injections, Intracytoplasmic*