We describe a neonate with hypoplastic left heart syndrome supported with venoarterial extracorporeal membrane oxygenation with a femoral arterial cannula. A 6-French straight sheath was percutaneously placed in the right femoral artery using the Seldinger technique. Adequate extracorporeal membrane oxygenation flows were achieved, and the patient was successfully de-cannulated. Femoral arterial cannulation in neonates is technically feasible and provides an alternative site for extracorporeal membrane oxygenation cannulation.