Objective: To investigate the toxicology and biodynamics of silica nanoparticle.
Methods: The silica nanoparticles were injected into mice through tail vein, and the mice were amphimixised, the urine was collected in different time, variations of pathology in organs and tissues of the mice were detected. At the same time, the silica nanoparticles' distribution in the tissues was observed through electron microscope.
Results: The silica nanoparticles were detected in all tissues and urine of the mice. The injected mice can reproduce as normal.
Conclusion: The silica nanoparticles do not have toxicity and can be used in vivo.