Abstract
Endosymbiotic Wolbachia bacteria that infect the filarial nematode Onchocerca volvulus were previously found to have an essential role in the pathogenesis of river blindness. The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / biosynthesis
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Adaptor Proteins, Signal Transducing / deficiency
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / physiology*
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Animals
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Disease Models, Animal
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Eye Infections, Bacterial / genetics
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Eye Infections, Bacterial / immunology*
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Keratitis / genetics
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Keratitis / immunology*
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Mice
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Mice, Knockout
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Myeloid Differentiation Factor 88
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Neutrophils / immunology
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Onchocerca volvulus / immunology*
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Onchocerciasis, Ocular / genetics
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Onchocerciasis, Ocular / immunology*
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Signal Transduction / genetics
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Signal Transduction / immunology
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Toll-Like Receptors / genetics
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Toll-Like Receptors / physiology
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Wolbachia / immunology*
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Wolbachia / pathogenicity
Substances
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Adaptor Proteins, Signal Transducing
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Myd88 protein, mouse
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Myeloid Differentiation Factor 88
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Toll-Like Receptors