Objective: To study the effect of the S-bioallethrin on human lymphocytes by microarray technique.
Methods: The changes of normal human lymphocytes treated with S-bioallethrin were examined with light microscope, flow cytometry, electron microscope, DNA ladder and microarray techniques.
Results: Morphological study showed that the lymphocytes underwent apoptosis after S-bioallethrin exposure, which as further confirmed by the expression changes of 346 genes.
Conclusion: S-bioallethrin can induce apoptosis of normal human lymphocytes and changes in their gene expression profiles.