Observations on the internal and surface morphology of malaria infected blood cells using optical and atomic force microscopy

Ang Li; Ammar H Mansoor; Kevin S W Tan; C T Lim

doi:10.1016/j.mimet.2006.01.009

Observations on the internal and surface morphology of malaria infected blood cells using optical and atomic force microscopy

J Microbiol Methods. 2006 Sep;66(3):434-9. doi: 10.1016/j.mimet.2006.01.009. Epub 2006 Mar 7.

Authors

Ang Li¹, Ammar H Mansoor, Kevin S W Tan, C T Lim

Affiliation

¹ Nano Biomechanics Laboratory, Division of Bioengineering and Department of Mechanical Engineering, National University of Singapore, Singapore 117576.

PMID: 16519955
DOI: 10.1016/j.mimet.2006.01.009

Abstract

We describe a simple and fast method to probe the morphological changes on the exterior and interior of a malaria infected erythrocyte at different stages of parasite development. This involves the imaging and scanning of Giemsa stained malaria infected erythrocytes using optical microscopy and atomic force microscopy, respectively.

MeSH terms

Animals
Azure Stains / chemistry*
Coloring Agents / chemistry*
Erythrocytes / parasitology*
Erythrocytes / ultrastructure
Humans
Microscopy, Atomic Force / methods*
Plasmodium falciparum / growth & development*
Plasmodium falciparum / ultrastructure

Substances

Azure Stains
Coloring Agents