Lessons learned from molecular defects in nuclear factor kappaB dependent signaling

Douglas R McDonald; Riny Janssen; Raif Geha

doi:10.1016/j.micinf.2005.10.030

Lessons learned from molecular defects in nuclear factor kappaB dependent signaling

Microbes Infect. 2006 Apr;8(4):1151-6. doi: 10.1016/j.micinf.2005.10.030. Epub 2006 Jan 19.

Authors

Douglas R McDonald¹, Riny Janssen, Raif Geha

Affiliation

¹ Division of Immunology, Children's Hospital, Boston and Department of Pediatrics, Harvard Medical School, Karp Family Research Building, One Blackfan Circle, Boston, MA 02115, USA.

PMID: 16517203
DOI: 10.1016/j.micinf.2005.10.030

Abstract

Nuclear factor (NF) kappaB is a ubiquitously expressed transcription factor that plays critical roles in normal development and inflammation. Characterization of naturally occurring defects in signaling pathways leading to activation of NFkappaB, complemented by mouse knockout models, has demonstrated the vital role of NFkappaB in normal host defense.

Publication types

Review

MeSH terms

Animals
Ectodermal Dysplasia / genetics
Ectodermal Dysplasia / physiopathology
Humans
I-kappa B Kinase / genetics
I-kappa B Proteins / genetics
Immunity, Active
Immunity, Innate
Mice
Mice, Knockout
Mutation
NF-kappa B / deficiency
NF-kappa B / genetics
NF-kappa B / immunology*
NF-kappa B / metabolism
Signal Transduction

Substances

I-kappa B Proteins
NF-kappa B
I-kappa B Kinase