Abstract
Chemicals and metal ions often induce allergic contact dermatitis. We review here recent advances in the development of in vitro assays for prediction of skin sensitizing potency based on chemical and biological reactivity as well as in the identification of physiological binding partners and immunological pathomechanisms of chemical and metal ion induced disease.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Allergens / immunology*
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Animals
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Dermatitis, Allergic Contact / diagnosis*
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Haptens / immunology
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Humans
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Hypersensitivity / immunology*
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Ions / immunology
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Metals / immunology*
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Metals / metabolism
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Nickel / immunology
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Protein Binding
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Proteins / immunology*
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Proteins / metabolism
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Proteomics
Substances
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Allergens
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Haptens
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Ions
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Metals
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Proteins
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Nickel