Studies on the novel alpha-glucosidase inhibitory activity and structure-activity relationships for andrographolide analogues

Bioorg Med Chem Lett. 2006 May 15;16(10):2710-3. doi: 10.1016/j.bmcl.2006.02.011. Epub 2006 Feb 28.

Abstract

A series of analogues of andrographolide were synthesized and evaluated as novel alpha-glucosidase inhibitors. Among them compound 23, 15-p-methoxylbenzylidene 14-deoxy-11,12-didehydroandrographolide, was a potent inhibitor against alpha-glucosidase whose IC(50) value was 16microM. The structure-activity relationships were also discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Enzyme Inhibitors / pharmacology*
  • Glycoside Hydrolase Inhibitors*
  • Rats
  • Structure-Activity Relationship

Substances

  • Diterpenes
  • Enzyme Inhibitors
  • Glycoside Hydrolase Inhibitors
  • andrographolide