X-gal inhibits the swarming of Vibrio species

J Microbiol Methods. 2006 Sep;66(3):552-5. doi: 10.1016/j.mimet.2006.01.004. Epub 2006 Feb 21.

Abstract

The expressional levels of genes in swarmer cells can be determined by a simple method using X-gal-containing semisolid agars and lacZ-fusion transcription reporter strains of the genes concerned. However, X-gal alone inhibited the swarming of Vibrio, regardless of their ability to digest X-gal. Moreover, X-gal inhibited the growth of V. vulnificus containing functional lacZ. These effects of X-gal itself should be carefully considered when trying to determine the expression levels of genes in swarming cells using X-gal-containing semisolid agar.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromogenic Compounds / pharmacology*
  • Galactosides / pharmacology*
  • Indoles / pharmacology*
  • Vibrio / drug effects*
  • Vibrio / physiology*

Substances

  • Chromogenic Compounds
  • Galactosides
  • Indoles
  • 5-bromo-4-chloro-3-indolyl beta-galactoside