Stereocontrolled formation of amino acids and N-heterocycles bearing a quaternary chiral carbon

Org Lett. 2006 Mar 2;8(5):939-42. doi: 10.1021/ol053061g.

Abstract

Stereocontrolled formation of tertiary or quaternary chiral carbons bearing nitrogen was achieved using the [3,3]-sigmatropic rearrangement of cyanate to isocyanate as a key element. A short and highly selective sequence of reactions, starting from p-menthane-3-carboxaldehyde, was developed leading to alpha,alpha-dialkylated alpha-amino acids or N-heterocycles, depending on the method of cleavage of the auxiliary.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis*
  • Amino Acids / chemistry
  • Biological Products / chemistry
  • Molecular Structure
  • Nitrogen / chemistry*
  • Stereoisomerism

Substances

  • Amino Acids
  • Biological Products
  • Nitrogen