Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases

Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. doi: 10.1002/anie.200502756.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Crystallography, X-Ray
  • DNA / metabolism
  • Enzyme Inhibitors* / chemistry
  • Enzyme Inhibitors* / pharmacology
  • Glutathione Reductase / antagonists & inhibitors*
  • Glutathione Reductase / genetics
  • Humans
  • Models, Molecular
  • Mutation
  • Organogold Compounds* / chemistry
  • Organogold Compounds* / pharmacology
  • Phosphines* / chemistry
  • Phosphines* / pharmacology
  • Recombinant Proteins / antagonists & inhibitors*
  • Recombinant Proteins / genetics
  • Thioredoxin-Disulfide Reductase / antagonists & inhibitors*
  • Thioredoxin-Disulfide Reductase / genetics

Substances

  • Enzyme Inhibitors
  • Organogold Compounds
  • Phosphines
  • Recombinant Proteins
  • DNA
  • Glutathione Reductase
  • Thioredoxin-Disulfide Reductase