Abstract
Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12( E)-dien-16-al (aframolin A) ( 1) and 8beta(17)-epoxy-15,15-dimethoxylabd-12( E)-en-16-al (aframolin B) ( 2), together with the known diterpenes labda-8(17),12( E)-diene-15,16-dial ( 3) and aframodial ( 4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Candida albicans / drug effects
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Cryptococcus neoformans / drug effects
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Methicillin Resistance
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Naphthalenes / chemistry
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Naphthalenes / pharmacology*
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Plant Preparations / chemistry
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Plant Preparations / pharmacology
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology*
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Staphylococcus aureus / drug effects
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Zingiberaceae / chemistry*
Substances
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Anti-Infective Agents
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Diterpenes
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Naphthalenes
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Plant Preparations
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Spiro Compounds
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8,17-epoxylabd-12-ene-15,16-dial