Fluoxetine alters mu opioid receptor expression in obese Zucker rat extrahypothalamic regions

Int J Neurosci. 2006 Mar;116(3):289-98. doi: 10.1080/00207450500403231.

Abstract

The aim of this article was to describe the effects of chronic fluoxetine on mu opioid receptor expression in obese Zucker rat extrahypothalamic regions. Male obese Zucker (fa/fa) rats were administered with fluoxetine (10 mg/kg; i.p.) daily for two weeks. Brain regional immunostaining for mu opioid receptor was carried out. An increase in the numbers of neural cells immunostained for mu opioid receptor in caudatus-putamen, dentate gyrus, lateral septum, amygdala, and frontal, parietal, and piriform cortices was observed. Increased mu opioid receptor expression in the central amygdaloid nuclei suggests a decreased opioidergic tone at this level that could be involved in fluoxetine anorectic action.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / drug effects*
  • Brain / metabolism
  • Cell Count
  • Disease Models, Animal
  • Fluoxetine / pharmacology*
  • Gene Expression / drug effects*
  • Immunohistochemistry / methods
  • Male
  • Obesity / drug therapy*
  • Rats
  • Rats, Zucker / metabolism
  • Receptors, Opioid, mu / genetics
  • Receptors, Opioid, mu / metabolism*
  • Selective Serotonin Reuptake Inhibitors / pharmacology*

Substances

  • Receptors, Opioid, mu
  • Serotonin Uptake Inhibitors
  • Fluoxetine