Abstract
A new steroidal glycoside has been isolated from the underground parts of Solanum sodomaeum L., along with seven known steroidal glycosides. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence, and the structure of one known pregnane type glycoside was corrected. In addition, their antiproliferative activity against human promyelocytic leukemia (HL-60) cells was investigated, and five compounds exhibited stronger activity than cisplatin.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Carbohydrate Sequence
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Cisplatin / pharmacology
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Drug Screening Assays, Antitumor
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Glycosides / chemistry*
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Glycosides / isolation & purification
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Glycosides / pharmacology
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HL-60 Cells
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Humans
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Hydrolysis
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Molecular Sequence Data
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Plant Roots / chemistry
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Solanum / chemistry*
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Spectrometry, Mass, Fast Atom Bombardment
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Steroids / chemistry*
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Steroids / isolation & purification
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Steroids / pharmacology
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Steroids
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Cisplatin