Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

J Enzyme Inhib Med Chem. 2005 Dec;20(6):525-32. doi: 10.1080/03067310500212037.

Abstract

Fifteen compounds derived from the 2(3H)-benzothiazolone template with an acyl side-chain in position-6 were evaluated for their lipid-lowering action in mice. Among these compounds, 6-benzoyl-2(3H)-benzothiazolone was found to be the most potent one both in mice models receiving a hypercholesterolemic diet (for 15 days) or a standard diet (for 21 days). 6-Benzoyl-2(3H)-benzothiazolone compares favorably with fenofibrate, the standard drug, both in terms of HDL-C/Chol (High Density Lipoprotein-Cholesterol/Total Cholesterol) ratio and absence of liver hepatomegaly.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzothiazoles / chemical synthesis
  • Benzothiazoles / chemistry*
  • Benzothiazoles / pharmacology*
  • Body Weight / drug effects
  • Diet
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Female
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / drug therapy*
  • Hypolipidemic Agents / chemical synthesis
  • Hypolipidemic Agents / chemistry*
  • Hypolipidemic Agents / pharmacology*
  • Lipids / blood
  • Mice
  • Molecular Structure
  • Organ Size / drug effects
  • Thiazoles / chemical synthesis
  • Thiazoles / chemistry*
  • Thiazoles / pharmacology*

Substances

  • 6-benzoyl-2(3H)-benzothiazolone
  • Benzothiazoles
  • Hypolipidemic Agents
  • Lipids
  • Thiazoles