Abstract
The authors used voxel-based morphometry to compare the patterns of brain atrophy in two variants of pathologically confirmed frontotemporal lobar degeneration (FTLD): FTLD with motor neuron disease (FTLD-MND) and FTLD with ubiquitin-only-immunoreactive neuronal changes (FTLD-U). Patterns of atrophy were distinct and different from each other. A localized pattern of frontal lobe atrophy was found in FTLD-MND with a more widespread pattern of atrophy affecting the frontal and temporal lobes in FTLD-U.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Age Factors
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Aged
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Atrophy / diagnosis*
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Brain / pathology*
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Brain / physiopathology
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Dementia / complications*
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Dementia / diagnosis*
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Dementia / physiopathology
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Female
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Humans
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Inclusion Bodies / metabolism
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Inclusion Bodies / pathology
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Motor Neuron Disease / complications*
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Motor Neuron Disease / diagnosis*
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Motor Neuron Disease / physiopathology
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Motor Neurons / metabolism
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Motor Neurons / pathology
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Predictive Value of Tests
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Retrospective Studies
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Sex Factors
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Survival Rate
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tau Proteins / metabolism