The role of the amygdala and rostral anterior cingulate in encoding expected outcomes during learning

Neuroimage. 2006 Feb 15;29(4):1161-72. doi: 10.1016/j.neuroimage.2005.07.060. Epub 2006 Jan 4.

Abstract

Successful passive avoidance learning is thought to require the use of learned stimulus-reinforcement associations to guide decision making [Baxter, M.G., Murray, E.A., 2002. The amygdala and reward. Nature Reviews. Neuroscience 3, 563-573]. The current experiment investigated the neural correlates of successful passive avoidance learning in 19 healthy adults. Behaviorally, subjects showed a distinct pattern of performance: early indiscriminate responding to stimuli (pre-criterion performance), followed by relatively rapid learning before a plateau of successful performance (post-criterion performance). Neural responses to post-criterion correct responses were compared with neural responses to both incorrect responses and pre-criterion correct responses. Post-criterion correct responding was associated with increased activation in regions including rostral anterior cingulate, insula, caudate, hippocampal regions, and the amygdala.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amygdala / blood supply
  • Amygdala / physiology*
  • Association Learning / physiology*
  • Avoidance Learning / physiology*
  • Brain / blood supply
  • Brain / physiology
  • Brain Mapping
  • Echo-Planar Imaging*
  • Female
  • Gyrus Cinguli / blood supply
  • Gyrus Cinguli / physiology*
  • Humans
  • Image Enhancement*
  • Image Processing, Computer-Assisted*
  • Male
  • Motivation*
  • Nerve Net / physiology
  • Neural Pathways / physiology
  • Oxygen / blood*
  • Serial Learning / physiology
  • Set, Psychology*

Substances

  • Oxygen