Abstract
Recently a novel family of putative nitric oxide synthases, with AtNOS1, the plant member implicated in NO production, has been described. Here we present experimental evidence that a mammalian ortholog of AtNOS1 protein functions in the cellular context of mitochondria. The expression data suggest that a candidate for mammalian mitochondrial nitric oxide synthase contributes to multiple physiological processes during embryogenesis, which may include roles in liver haematopoesis and bone development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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COS Cells
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Chlorocebus aethiops
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Embryo, Mammalian / anatomy & histology
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Humans
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In Situ Hybridization
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Isoenzymes / genetics
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Isoenzymes / metabolism*
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Mice
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Mitochondria / enzymology*
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Mitochondria / ultrastructure
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Molecular Sequence Data
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NIH 3T3 Cells
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Nitric Oxide Synthase / genetics
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Nitric Oxide Synthase / metabolism*
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Protein Sorting Signals
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Sequence Alignment
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Tissue Distribution
Substances
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Isoenzymes
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Protein Sorting Signals
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Recombinant Fusion Proteins
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Nitric Oxide Synthase