Abstract
Transcutaneous immunization of mice with recombinant protective antigen (rPA) of Bacillus anthracis resulted in significantly higher lethal toxin-neutralizing antibody titers than did intramuscular injection of alum-adsorbed rPA. Immunized mice were partially protected against intranasal challenge with 235,000 (10 50% lethal doses) Ames strain B. anthracis spores. A highly significant correlation was observed between toxin-neutralizing antibody titer and survival after challenge. Future experiments with rabbits and nonhuman primates should confirm the significance of protection by this vaccine strategy.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Administration, Cutaneous
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Animals
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Anthrax / immunology*
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Anthrax / prevention & control
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Anthrax Vaccines / administration & dosage
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Anthrax Vaccines / genetics
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Anthrax Vaccines / immunology*
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology*
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Antigens, Bacterial / therapeutic use
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Bacillus anthracis / genetics
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Bacillus anthracis / immunology*
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Female
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Mice
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Mice, Inbred CBA
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Spores, Bacterial / immunology
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Vaccines, Synthetic / administration & dosage
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Vaccines, Synthetic / genetics
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Vaccines, Synthetic / immunology
Substances
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Anthrax Vaccines
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Antigens, Bacterial
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Vaccines, Synthetic