Equal proportions of affected cells in muscle and blood of a mosaic carrier of facioscapulohumeral muscular dystrophy

Hum Genet. 2006 Mar;119(1-2):23-8. doi: 10.1007/s00439-005-0100-2. Epub 2005 Dec 8.

Abstract

Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) is associated with contractions of D4Z4 repeat on 4q35. It displays a remarkable inter- and intra-familial clinical variability ranging from severe phenotype to asymptomatic carriers. Mosaicism for the contracted FSHD-sized allele is a recurrent finding, but only DNA from lymphocytes had been studied. It is currently not known if mosaicism is unequally distributed between different tissues and if muscle is relatively spared for the presence of the disease allele in mosaic asymptomatic carriers of a disease allele. Here we compare DNA extracted from peripheral blood lymphocytes (PBL), fibroblasts and muscle from a mosaic asymptomatic female carrier and mother of a FSHD patient. PFGE analysis showed a complex allelic segregation: two independent mitotic rearrangement episodes occurred, resulting in mosaicism for a contracted D4Z4 repeat on 4q35 in the mother and mosaicism for an expanded D4Z4 repeat on 10q26 in the affected daughter. The results show that the proportion of mosaicism in PBL and muscle were comparable, while in fibroblasts there was some variation in the mosaicism, which might be caused by culturing artefacts. This finding supports the hypothesis that a mitotic contraction of D4Z4 is an early embryonic event and indicates that the degree of mosaicism in PBL is representative for that of muscle.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Chromosomes, Human, Pair 4
  • DNA / genetics
  • DNA / metabolism
  • Deoxyribonuclease EcoRI / metabolism
  • Deoxyribonuclease HindIII / metabolism
  • Electrophoresis, Gel, Pulsed-Field
  • Family Health
  • Female
  • Fibroblasts / metabolism
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Mosaicism*
  • Muscles / metabolism
  • Muscular Dystrophy, Facioscapulohumeral / blood
  • Muscular Dystrophy, Facioscapulohumeral / genetics
  • Muscular Dystrophy, Facioscapulohumeral / pathology*
  • Pedigree
  • Repetitive Sequences, Nucleic Acid / genetics*

Substances

  • DNA
  • Deoxyribonuclease EcoRI
  • Deoxyribonuclease HindIII