Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts

Cancer Lett. 2006 Sep 8;241(1):87-92. doi: 10.1016/j.canlet.2005.10.003. Epub 2005 Dec 9.

Abstract

The impact of poly(ADP-ribose) polymerase-1 (Parp-1)-deficiency on 4-nitroquinoline 1-oxide (4NQO)-induced carcinogenesis was studied in mice with an ICR/129Sv mixed genetic background. Parp-1(+/+), Parp-1(+/-) and Parp-1(-/-) animals given 4NQO for thirty-two weeks at 0.001% in their drinking water developed papillomas and squamous cell carcinomas of the tongue, palate and esophagus, but with no statistically significant variation with the Parp-1 genotype. Thus Parp-1 deficiency does not elevate susceptibility to carcinogenesis induced by a carcinogen which gives rise to bulky DNA lesions. This study also indicated that the ICR/129Sv mixed genetic background is associated with high yield induction of esophageal tumors by 4NQO.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Nitroquinoline-1-oxide / toxicity*
  • Animals
  • Carcinogens / toxicity*
  • Esophageal Neoplasms / chemically induced*
  • Esophageal Neoplasms / genetics
  • Esophageal Neoplasms / physiopathology
  • Mice
  • Mice, Inbred ICR
  • Mice, Knockout
  • Mouth Neoplasms / chemically induced*
  • Mouth Neoplasms / genetics
  • Mouth Neoplasms / physiopathology
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases / genetics
  • Poly(ADP-ribose) Polymerases / physiology*

Substances

  • Carcinogens
  • 4-Nitroquinoline-1-oxide
  • PARP1 protein, human
  • Poly (ADP-Ribose) Polymerase-1
  • Poly(ADP-ribose) Polymerases