eIF3: a connecTOR of S6K1 to the translation preinitiation complex

Tim R Peterson; David M Sabatini

doi:10.1016/j.molcel.2005.11.016

eIF3: a connecTOR of S6K1 to the translation preinitiation complex

Mol Cell. 2005 Dec 9;20(5):655-7. doi: 10.1016/j.molcel.2005.11.016.

Authors

Tim R Peterson¹, David M Sabatini

Affiliation

¹ The Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA.

PMID: 16337588
DOI: 10.1016/j.molcel.2005.11.016

Abstract

In the November 18 issue of Cell, discover an unidentified function for the eIF3 translation initiation factor as a scaffold for the dynamic associations of many preinitiation complex components, including the growth-regulating kinases mTOR and S6K1.

Publication types

Review

MeSH terms

Animals
Eukaryotic Initiation Factor-3 / chemistry
Eukaryotic Initiation Factor-3 / metabolism*
Models, Biological
Protein Kinases / chemistry
Protein Kinases / metabolism*
Ribosomal Protein S6 Kinases, 70-kDa / chemistry
Ribosomal Protein S6 Kinases, 70-kDa / metabolism*
TOR Serine-Threonine Kinases

Substances

Eukaryotic Initiation Factor-3
Protein Kinases
Ribosomal Protein S6 Kinases, 70-kDa
TOR Serine-Threonine Kinases