Microbial transformation of fraxinellone by Aspergillus niger

R-L Yang; T-L Jia; R-Q Zhang

doi:10.1080/10286020310001653318

Microbial transformation of fraxinellone by Aspergillus niger

J Asian Nat Prod Res. 2005 Dec;7(6):843-5. doi: 10.1080/10286020310001653318.

Authors

R-L Yang¹, T-L Jia, R-Q Zhang

Affiliation

¹ Institute of Marine Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China.

PMID: 16308202
DOI: 10.1080/10286020310001653318

Abstract

Microbial transformation of fraxinellone (1) by Aspergillus niger (AS 3.421) has been carried out. Two converted products, dasycarpol (2) and a new compound fraxinigerllone (3) were obtained. Their structures have been identified on the basis of spectroscopic methods. Dasycarpol shows moderate inhibitory activity on lung cancer cell line A549.

MeSH terms

Antineoplastic Agents, Phytogenic / metabolism*
Antineoplastic Agents, Phytogenic / pharmacology
Aspergillus niger / metabolism*
Benzofurans / metabolism*
Benzofurans / pharmacology
Cell Line, Tumor
Dictamnus / chemistry*
Humans
Mass Spectrometry
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Plants, Medicinal / chemistry

Substances

Antineoplastic Agents, Phytogenic
Benzofurans
fraxinellone