Expanding functionality of RNA: synthesis and properties of RNA containing imidazole modified tandem G-U wobble base pairs

Chem Commun (Camb). 2005 Dec 14:(46):5778-80. doi: 10.1039/b510846b. Epub 2005 Oct 20.

Abstract

Imidazole modification at C-5 of uridine that is part of tandem G-U wobble base pairs causes slight reduction of thermal stability (DeltaDeltaG(0)(310) < 0.4 kcal mol(-1)) and relatively small change in hydration of short RNA helices.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Pairing*
  • Guanine Nucleotides / chemistry*
  • Imidazoles / chemistry*
  • RNA / chemistry*
  • Transition Temperature
  • Uracil Nucleotides / chemistry*
  • Water / chemistry

Substances

  • Guanine Nucleotides
  • Imidazoles
  • Uracil Nucleotides
  • Water
  • RNA
  • imidazole