Inhibitory effect of Aucubin isolated from Eucommia ulmoides against UVB-induced matrix metalloproteinase-1 production in human skin fibroblasts

Biosci Biotechnol Biochem. 2005 Nov;69(11):2227-31. doi: 10.1271/bbb.69.2227.

Abstract

Of 30 herbal plants tested, the methanol extracts of Eucommia ulmoides (52%), Evodia officinalis (45%), and Pleuropterus multiflorus (41%) each showed a potent inhibitory effect on the matrix metalloproteinase-1 (MMP-1) production in ultraviolet B (UVB)-irradiated human fibroblasts. Aucubin was isolated as the MMP-1 inhibitor from E. ulmoides, and significantly suppressed the production of MMP-1 by nearly 57% compared to the control. It also reduced MMP-1 mRNA expression. These results suggest that aucubin is a photoprotective phytochemical, and could be used as a potential agent in preventing photoaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Eucommiaceae / chemistry*
  • Fibroblasts / enzymology*
  • Fibroblasts / metabolism
  • Gene Expression Regulation, Enzymologic / drug effects
  • Gene Expression Regulation, Enzymologic / radiation effects*
  • Glucosides / isolation & purification
  • Glucosides / pharmacology*
  • Humans
  • Iridoid Glucosides
  • Iridoids / isolation & purification
  • Iridoids / pharmacology*
  • Matrix Metalloproteinase 1 / biosynthesis*
  • Plant Extracts
  • RNA, Messenger / analysis
  • Radiation-Protective Agents / isolation & purification
  • Radiation-Protective Agents / pharmacology
  • Skin / cytology
  • Ultraviolet Rays*

Substances

  • Glucosides
  • Iridoid Glucosides
  • Iridoids
  • Plant Extracts
  • RNA, Messenger
  • Radiation-Protective Agents
  • aucubin
  • Matrix Metalloproteinase 1