Abstract
Immunosuppressed mice were infected intravenously with conidia of Scedosporium prolificans. Treatment was begun 1 day later with liposomal amphotericin B, caspofungin, or both drugs initiated concurrently. Amphotericin B and caspofungin were each effective, but combined therapy did not appear to offer advantages over liposomal amphotericin B alone.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / therapeutic use*
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Animals
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Antifungal Agents / administration & dosage
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Antifungal Agents / therapeutic use*
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Caspofungin
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Dose-Response Relationship, Drug
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Drug Interactions
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Drug Therapy, Combination
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Echinocandins
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Lipopeptides
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Mice
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Mycetoma / drug therapy*
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Peptides, Cyclic / therapeutic use*
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Scedosporium*
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides, Cyclic
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liposomal amphotericin B
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Amphotericin B
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Caspofungin