Abstract
We constructed Salmonella enterica serovar Typhimurium double-knockout mutants in which either the lipoprotein A (lppA) or the lipoprotein B (lppB) gene was deleted from an msbB-negative background strain by marker exchange mutagenesis. These mutants were highly attenuated when tested with in vitro and in vivo models of Salmonella pathogenesis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acyltransferases / genetics
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Animals
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Bacterial Proteins / genetics*
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Bacterial Proteins / immunology
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Gene Deletion
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Immune Sera / immunology
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Lipopolysaccharides / immunology
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Lipoprotein(a) / genetics
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Lipoprotein(a) / immunology
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Lipoproteins / genetics*
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Lipoproteins / immunology
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Mice
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Mutation
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Salmonella Infections / immunology
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Salmonella Infections / microbiology*
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Salmonella typhimurium / genetics
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Salmonella typhimurium / immunology
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Salmonella typhimurium / pathogenicity*
Substances
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Bacterial Proteins
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Immune Sera
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Lipopolysaccharides
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Lipoprotein(a)
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Lipoproteins
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Acyltransferases