Degradation of lansoprazole and omeprazole in the aquatic environment

M DellaGreca; M R Iesce; L Previtera; M Rubino; F Temussi; M Brigante

doi:10.1016/j.chemosphere.2005.09.003

Degradation of lansoprazole and omeprazole in the aquatic environment

Chemosphere. 2006 May;63(7):1087-93. doi: 10.1016/j.chemosphere.2005.09.003. Epub 2005 Nov 9.

Authors

M DellaGreca¹, M R Iesce, L Previtera, M Rubino, F Temussi, M Brigante

Affiliation

¹ UDR Napoli 4 (Consorzio INCA)-Dipartimento di Chimica Organica e Biochimica, Università di Napoli Federico II, Via Cinthia 4, I-80126 Napoli, Italy.

PMID: 16289231
DOI: 10.1016/j.chemosphere.2005.09.003

Abstract

Lansoprazole and omeprazole degrade in water leading to sulfides, benzimidazolones and a red complex material. Degradation is accelerated in acid medium and by solar simulator irradiation. Benzimidazoles, dianilines and pyridines have also been identified.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

2-Pyridinylmethylsulfinylbenzimidazoles
Hydrogen-Ion Concentration
Hydrolysis
Lansoprazole
Magnetic Resonance Spectroscopy
Molecular Structure
Omeprazole / analogs & derivatives*
Omeprazole / analysis*
Omeprazole / chemistry
Omeprazole / radiation effects
Photochemistry
Ultraviolet Rays
Water Pollutants, Chemical / analysis*
Water Pollutants, Chemical / radiation effects

Substances

2-Pyridinylmethylsulfinylbenzimidazoles
Water Pollutants, Chemical
Lansoprazole
Omeprazole