Cardio-vascular diseases (CVD) are the leading cause of death. The MyHeart Project aims at empowering the citizens to fight cardio-vascular diseases by preventive lifestyle and early diagnosis. The main technical challenges in this project are the combination of novel wearable technologies (novel textile and electronic sensors, personalised algorithms, on-body computing) and user feedback and motivation concepts, in order to make a breakthrough towards new applications for prevention and early diagnose possible.