Effect of cetrorelix acetate on apoptosis and apoptosis regulatory factors in cultured uterine leiomyoma cells

Fertil Steril. 2005 Nov;84(5):1526-8. doi: 10.1016/j.fertnstert.2005.06.022.

Abstract

This report suggests the possibility that a gonadotropin-releasing hormone (GnRH) antagonist initiates apoptosis not only by causing a sex hormone deficit by inhibiting GnRH secretion in the pituitary gland, but also by acting directly on leiomyoma cells promoting apoptosis.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Apoptosis / drug effects*
  • Apoptosis / physiology
  • Female
  • Gonadotropin-Releasing Hormone / analogs & derivatives*
  • Gonadotropin-Releasing Hormone / pharmacology
  • Humans
  • Leiomyoma / metabolism*
  • Leiomyoma / pathology*
  • Tumor Cells, Cultured
  • Uterus / drug effects*
  • Uterus / metabolism
  • Uterus / pathology*

Substances

  • Gonadotropin-Releasing Hormone
  • cetrorelix