NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

Nat Med. 2005 Nov;11(11):1135-6; author reply 1136-7. doi: 10.1038/nm1105-1135.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Comment

MeSH terms

  • Amino Acid Sequence
  • Binding Sites
  • Chromatography, Affinity
  • DNA-Binding Proteins / metabolism*
  • Diffusion
  • Gene Deletion
  • Glutathione Transferase / metabolism
  • Histidine / chemistry
  • Humans
  • Kinetics
  • Neoplasm Proteins / metabolism*
  • Nitrogen Isotopes / metabolism
  • Nuclear Magnetic Resonance, Biomolecular*
  • Protein Binding
  • Protein Conformation
  • Protein Folding
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-mdm2 / chemistry
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Protons
  • Recombinant Fusion Proteins / metabolism
  • Spectrometry, Fluorescence
  • Titrimetry
  • Tumor Suppressor Protein p53 / chemistry
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / isolation & purification
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • DNA-Binding Proteins
  • Neoplasm Proteins
  • Nitrogen Isotopes
  • Protons
  • Recombinant Fusion Proteins
  • Tumor Suppressor Protein p53
  • ZNF331 protein, human
  • Histidine
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Glutathione Transferase